Is antidepressants toxic to dogs?
Human antidepressants can cause serotonin syndrome in dogs: agitation, tremors and overheating. The danger depends on the specific drug and dose, so the bottle is your most important piece of information. The toxic principle is serotonergic and other neuroactive drugs; overdose causes serotonin syndrome.
Toxic dose by dog weight
There is no reliable numeric toxic dose for antidepressants in dogs, so we don't show a weight-band table — inventing one would be misleading. No single threshold — varies by drug. Some (e.g. bupropion, venlafaxine, tricyclics) cause signs at low doses. Bring the bottle. Smaller dogs (toy and small breeds) are generally at higher risk from any given amount.
Symptoms timeline
0–2 hours: sedation or agitation, vomiting, drooling.
2–12 hours: dilated pupils, tremors, racing heart, high body temperature.
12–72 hours: seizures, prolonged signs with extended-release drugs.
Go to the vet / call ASPCA Animal Poison Control (888) 426-4435 now if…
- Your dog ate any antidepressant
- Your dog is trembling, agitated, overheating or very sedated
- You are unsure what or how much your dog ate
- Your dog is very young, old, pregnant or has heart, liver or kidney disease
First aid: do's and don'ts
Do:
- Move your dog away from the source and remove any remaining material from their mouth if it is safe to do so
- Keep the packaging, label or a sample/photo of what was eaten
- Note your dog's weight, the approximate amount and the time of ingestion
- Call your vet or a pet poison hotline right away
Don't:
- Never induce vomiting without veterinary advice — for some substances it causes more harm
- Don't give salt, hydrogen peroxide, oils or home remedies unless a vet tells you to
- Don't wait for symptoms if the substance is highly toxic
- Don't give human medicines to treat symptoms
How vets treat antidepressants exposure
Treatment depends on the amount, time since ingestion and your dog's signs. It may include decontamination when appropriate, activated charcoal for some toxins, IV fluids, medications to control signs, and monitoring. Bring the packaging so your vet can tailor treatment.
Prognosis
Most dogs treated early do well. The outlook depends on the dose, how quickly care begins, and your dog's overall health. Severe or delayed cases carry a more guarded prognosis.
What to do now
Call your veterinarian or an animal poison-control service for exposure-specific advice. Dog poison control: phone numbers, fees and when to call.